Elemental Tomography of Cancer-Cell Spheroids Reveals Incomplete Uptake of Both Platinum(II) and Platinum(IV) Complexes
Journal of the American Chemical Society2007Vol. 129(44), pp. 13400–13401
Citations Over TimeTop 10% of 2007 papers
Rebecca A. Alderden, Howard R. Mellor, Szabolcs Modok, Matthew D. Hall, S. R. Sutton, M. Newville, Richard Callaghan, Trevor W. Hambley
Abstract
The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor spheroids, models of solid tumors. This has revealed that there is no significant difference between the distributions of the range of Pt(II) and Pt(IV) complexes investigated, suggesting that complexes that are more resistant to cellular uptake may be needed to ensure more complete distribution throughout a tumor.
Related Papers
- → Media additives to promote spheroid circularity and compactness in hanging drop platform(2014)128 cited
- → Kinetics of Hepatocyte Spheroid Formation(1994)66 cited
- → Growth and characterization of multicellular tumor spheroids of human bladder carcinoma origin(1986)16 cited
- → Bio Rapid Prototyping Project: Development of Spheroid Formation System for Regenerative Medicine(2013)2 cited
- Bio Rapid Prototyping Project: Development of Spheroid Formation System for Regenerative Medicine.(2013)