Highly Chemoselective Metal-Free Reduction of Tertiary Amides
Journal of the American Chemical Society2007Vol. 130(1), pp. 18–19
Citations Over TimeTop 10% of 2007 papers
Abstract
This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.
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