Gadolinium Chelate Coated Gold Nanoparticles As Contrast Agents for Both X-ray Computed Tomography and Magnetic Resonance Imaging
Journal of the American Chemical Society2008Vol. 130(18), pp. 5908–5915
Citations Over TimeTop 1% of 2008 papers
Christophe Alric, Jacqueline Taleb, Géraldine Le Duc, Céline A. Mandon, Claire Billotey, Alice Le Meur-Herland, Thierry Brochard, Francis Vocanson, M. Janier, Pascal Perriat, Stéphane Roux, Olivier Tillement
Abstract
Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in the lungs, spleen, and liver.
Related Papers
- → Design and synthesis of novel DOTA(Gd3+)–polymer conjugates as potential MRI contrast agents(2011)31 cited
- → Binding of a dimeric manganese porphyrin to serum albumin: towards a gadolinium-free blood-pool T 1 MRI contrast agent(2014)27 cited
- → Block Copolymer-Based Gadolinium Nanoparticles as MRI Contrast Agents with High T 1 Relaxivity(2012)21 cited
- → A self-assembly heterotrinuclear gadolinium(III)–iron(II) complex as a MRI contrast agent(2011)13 cited
- Relaxivities of Gadolinium Heteropoly Complexes in Aqueous Solution for MRI Contrast Agent(2000)