Direct Observation of Morphological Tranformation from Twisted Ribbons into Helical Ribbons
Citations Over TimeTop 1% of 2010 papers
Abstract
We report on the direct observation of a nanostructural transformation from a twisted ribbon to a helical ribbon in supramolecular assemblies of peptide amphiphiles. Using cryogenic electron microscopy, a peptide amphiphile molecule containing aromatic residues was found to first assemble into short twisted ribbons in the time range of seconds, which then elongate in the time scale of minutes, and finally transform into helical ribbons over the course of weeks. By synthesizing an analogous molecule without the aromatic side groups, it was found that a cylindrical nanostructure is formed that does not undergo any transitions during the same time period. The study of metastable states in peptide aggregation can contribute to our understanding of amyloid-related diseases, such as Alzheimer's disease.
Related Papers
- → CO2-Enhanced Bola-Type Supramolecular Amphiphile Constructed from Pillar[5]arene-Based Host–Guest Recognition(2018)19 cited
- → High speed EFG of wide silicon ribbon(1980)44 cited
- → Ultrasonic Bonding of Ag Ribbon on Si Wafers With Various Backside Metallization(2023)1 cited
- → Factors Controlling Thickness of Amorphous Ribbon in Single Roller Process(1992)3 cited
- → Alexander polynomials of ribbon knots and virtual knots(2021)