Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems
Journal of the American Chemical Society2010Vol. 132(17), pp. 5938–5939
Citations Over TimeTop 10% of 2010 papers
Abstract
We describe here the new copper-selective fluorescent probes FluTPA1 and FluTPA2, in which the tetradentate ligand tris[(2-pyridyl)methyl]amine (TPA) is connected to a reduced form of a fluorescein platform through a benzyl ether linkage. These probes selectively react with copper ions in the presence of submillimolar glutathione and emit intense green fluorescence from the reaction product, O-methylfluorescein. Confocal images of live cells further show that FluTPA2 is membrane-permeable and allows visualization of CuI present in living cells.
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