Copper-Catalyzed Intramolecular C−H Oxidation/Acylation of Formyl-N-arylformamides Leading to Indoline-2,3-diones
Journal of the American Chemical Society2010Vol. 132(26), pp. 8900–8902
Citations Over TimeTop 1% of 2010 papers
Bo‐Xiao Tang, Ren‐Jie Song, Cuiyan Wu, Yu Liu, Mingbo Zhou, Wen‐Ting Wei, Guobo Deng, Dulin Yin, Jin‐Heng Li
Abstract
A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl(2) and O(2), a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.
Related Papers
- → Syntheses of Heterocycle-2,3-Fused Indoline and Azaindoline Derivatives(2021)10 cited
- → Synthese De Quelques Spiro[Indoline‐Naphtoxazines] Et Spiro[Indoline‐Pyridobenzoxazines] Photochromiques. Application De La Methodologie De La Recherche Experimentale(1992)45 cited
- → Triple domino reaction for the synthesis of pyrazole/indoline linked chromenes(2017)9 cited
- → Diastereoselective Synthesis of Functionalized Indoline N,O‐Aminals: Unexpected Water‐Involved Cascade Reaction of 3H‐Indoles and Oxazol‐5‐(4H)ones(2019)1 cited
- → A synthesis of functionalized indoline 2,2-biscarboxylates(1996)5 cited