A Responsive Europium(III) Chelate That Provides a Direct Readout of pH by MRI
Journal of the American Chemical Society2010Vol. 132(40), pp. 14002–14003
Citations Over TimeTop 10% of 2010 papers
Abstract
A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.
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