Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications
Citations Over TimeTop 10% of 2010 papers
Abstract
Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.
Related Papers
- → A comparison of in vivo and in vitro methods for determining availability of iron from meals(1981)109 cited
- → Studies on pharmacokinetics of sulfonated aluminum phthalocyanine in a transplantable mouse tumor by in vivo fluorescence(1993)8 cited
- → Methods for obtaining and processing biocompatible medical materials(2019)
- → [Research advances on the application of biocompatible materials in treating diabetic wounds].(2021)
- → CHEMICAL COMPOSITIONS AND ANALYSIS OF BIOCOMPATIBLE MATERIAL(S), TECHNOLOGICAL ADVANCEMENT AND STANCE(2022)