Cobalt-Catalyzed Hydroarylation of Alkynes through Chelation-Assisted C−H Bond Activation
Journal of the American Chemical Society2010Vol. 132(35), pp. 12249–12251
Citations Over TimeTop 1% of 2010 papers
Abstract
Ternary catalytic systems consisting of cobalt salts, phosphine ligands, and Grignard reagents promote addition of arylpyridines and imines to unactivated internal alkynes with high regio- and stereoselectivities. Deuterium-labeling experiments suggest that the reaction involves chelation-assisted oxidative addition of the aryl C-H bond to the cobalt center and insertion of the C-C triple bond into the Co-H bond, followed by reductive elimination of the resulting diorganocobalt species.
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