Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
Journal of the American Chemical Society2011Vol. 133(18), pp. 6865–6867
Citations Over TimeTop 10% of 2011 papers
Jae‐Hyuk Jang, Yukihiro Asami, Jun‐Pil Jang, Sun-Ok Kim, Dong Oh Moon, Kee‐Sun Shin, Daisuke Hashizume, Makoto Muroi, Tamio Saito, Hyuncheol Oh, Bo Yeon Kim, Hiroyuki Osada, Jong Seog Ahn
Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.
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