Palladium-Catalyzed Mono-α-arylation of Acetone with Aryl Halides and Tosylates
Journal of the American Chemical Society2011Vol. 133(14), pp. 5194–5197
Citations Over TimeTop 10% of 2011 papers
Abstract
We report the first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs(2)CO(3) as the base and employing acetone as both a reagent and the solvent.
Related Papers
- → Preparation of organo palladium sols from palladium complexes in various alcohols(1994)32 cited
- → The constitution of cerium-palladium alloys containing 50–100% palladium(1967)48 cited
- → Allyl(β‐diketonato)palladium(II) complexes as precursors for palladium films(1994)36 cited
- → Reduction of palladium(II) monoglycinate complexes at rotating disc palladium electrode in acid media(2010)1 cited
- Rapid Determination of Palladium in Palladium-Nickel and Palladium-Cobalt Plating Bath(2003)