Catalytic Asymmetric Synthesis of Trisubstituted Aziridines
Journal of the American Chemical Society2011Vol. 133(23), pp. 8892–8895
Citations Over TimeTop 10% of 2011 papers
Abstract
A method is described which provides for the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds. While unactivated imines were not reactive to α-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with both α-diazo esters and α-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectivities.
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