Enantioselective Total Synthesis of (−)-Kibdelone C
Journal of the American Chemical Society2011Vol. 133(26), pp. 9956–9959
Citations Over TimeTop 10% of 2011 papers
Abstract
The kibdelones are aromatic polyketide natural products featuring isoquinolinone and tetrahydroxanthone ring systems. They display potent cytotoxicity toward a range of human cancer cell lines. Here, we present an enantioselective total synthesis of kibdelone C that utilizes a Shi epoxidation to establish the absolute and relative stereochemistry, an acid-catalyzed cyclization to form the tetrahydroxanthone, and a C-H arylation to complete the hexacyclic skeleton.
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