Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release
Journal of the American Chemical Society2011Vol. 133(49), pp. 19582–19585
Citations Over TimeTop 1% of 2011 papers
Neetu Singh, Amrita Karambelkar, Luo Gu, Kevin Lin, Jordan S. Miller, Christopher S. Chen, Michael J. Sailor, Sangeeta N. Bhatia
Abstract
Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.
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