Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones

Citations Over TimeTop 10% of 2011 papers

Abstract

A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.

Related Papers

• → Enantioselective Hydrogenation of Diarylmethanimines for Synthesis of Chiral Diarylmethylamines(2016)41 cited
• → Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands(2021)8 cited
• → Synthesis and application in enantioselective hydrogenation of a rhodium complex of an asymmetric water-soluble diphosphine PGE-17-DIOP(1984)48 cited
• → Rhodium‐Catalyzed Asymmetric Hydrogenation(2005)40 cited
• → Reduction of Functionalized Alkenes(2008)5 cited