Lab-on-a-Bubble: Synthesis, Characterization, and Evaluation of Buoyant Gold Nanoparticle-Coated Silica Spheres
Citations Over TimeTop 15% of 2011 papers
Abstract
This paper describes the development and preparation of a new class of materials for surface-enhanced Raman scattering (SERS) consisting of gold nanoparticles coated onto hollow, buoyant silica microspheres. These materials allow for a new type of molecular assay designated as a lab-on-a-bubble (LoB). LoB materials serve as a convenient platform for the detection of analytes in solution and offer several advantages over traditional colloidal gold and planar SERS substrates, such as the ability to localize and concentrate analytes for detection. An example assay is presented using the LoB method and cyanide detection. Cyanide binds to SERS-active, gold-coated LoBs and is detected directly from the corresponding SERS signal. The abilities of LoBs and a gold colloid to detect cyanide are compared, and in both cases, a detection limit of ~170 ppt was determined. Differences in measurement error using LoBs versus gold colloid are also described, as well as an assay for 5,5'-dithiobis(2-nitrobenzoic acid) that shows the benefit of using LoBs over SERS analyses in colloids, which are often plagued by particle aggregation.
Related Papers
- → Construction of simple gold nanoparticle aggregates with controlled plasmon–plasmon interactions(1999)158 cited
- → The Effect of pH-adjusted Gold Colloids on the Formation of Gold Clusters over APTMS-coated Silica Cores(2006)50 cited
- → Reversible formation of gold nanoparticle–surfactant composite assemblies for the preparation of concentrated colloidal solutions(2009)27 cited
- Surface plasmon resonance effects of gold colloids on optical properties of N719 dye in ethanol(2015)
- → On Optical Properties of Dilute Colloidal Gold(2011)3 cited