Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles
Journal of the American Chemical Society2011Vol. 133(50), pp. 20168–20171
Citations Over TimeTop 1% of 2011 papers
Abstract
We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO(2)) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO(2) into Mn(2+). The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.
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