Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions
Journal of the American Chemical Society2012Vol. 134(7), pp. 3326–3329
Citations Over TimeTop 10% of 2012 papers
Bärbel Lorenz, Luı́s Álvarez de Cienfuegos, Marieelen Oelkers, Ella Kriemen, Christian Brand, Milena Stephan, Eva Sunnick, Deniz Yüksel, Venkateshwarlu Kalsani, Krishna Kumar, Daniel B. Werz, Andreas Janshoff
Abstract
The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone.
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