Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature
Journal of the American Chemical Society2011Vol. 134(2), pp. 878–881
Citations Over TimeTop 1% of 2011 papers
Abstract
A palladium-catalyzed intramolecular oxidative aryltrifluoromethylation reaction of activated alkenes has been explored. The reaction allows for an efficient synthesis of a variety of CF(3)-containing oxindoles. Preliminary mechanistic study indicated that the reaction involves a C(sp(3))-Pd(IV)(CF(3)) intermediate, which undergoes reductive elimination to afford a C(sp(3))-CF(3) bond.
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