Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes
Journal of the American Chemical Society2012Vol. 134(24), pp. 9914–9917
Citations Over TimeTop 10% of 2012 papers
Abstract
A cell-specific metabolic glycan labeling strategy has been developed using azidosugars encapsulated in ligand-targeted liposomes. The ligands are designed to bind specific cell-surface receptors that are only expressed or up-regulated in target cells, which mediates the intracellular delivery of azidosugars. The delivered azidosugars are metabolically incorporated into cell-surface glycans, which are then imaged via a bioorthogonal reaction.
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