An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553
Journal of the American Chemical Society2012Vol. 134(30), pp. 12855–12860
Citations Over TimeTop 10% of 2012 papers
Abstract
The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps.
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