How Can Proteins Enter the Interior of a MOF? Investigation of Cytochrome c Translocation into a MOF Consisting of Mesoporous Cages with Microporous Windows
Journal of the American Chemical Society2012Vol. 134(32), pp. 13188–13191
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Yao Chen, Vasiliki Lykourinou, Carissa M. Vetromile, Tran Hoang, Li‐June Ming, Randy W. Larsen, Shengqian Ma
Abstract
It has been demonstrated for the first time that the heme protein cytochrome c (Cyt c) can enter the interior of a MOF despite the larger molecular dimension of the protein relative to the access pore sizes. Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores.
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