A Concise Synthesis of (+)-Artemisinin
Journal of the American Chemical Society2012Vol. 134(33), pp. 13577–13579
Citations Over TimeTop 10% of 2012 papers
Abstract
Malaria represents one of the most medically and economically debilitating diseases present in the world today. Fortunately, there exists a highly effective treatment based on the natural product artemisinin. Despite the development of several synthetic approaches to the natural product, a streamlined synthesis that utilizes low-cost chemical inputs has yet to materialize. Here we report an efficient, cost-effective approach to artemisinin. Key to the success of the strategy was the development of mild, complexity-building reaction cascades that allowed the use of readily available, affordable cyclohexenone as the key starting material.
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