Total Synthesis of (±)-Communesin F via a Cycloaddition with Indol-2-one
Journal of the American Chemical Society2012Vol. 134(41), pp. 16941–16943
Citations Over TimeTop 10% of 2012 papers
Abstract
A concise total synthesis of (±)-communesin F has been completed in 15 linear steps from 4-bromotryptophol in an overall yield of 6.7%. A key step features the cycloaddition of indol-2-one with 3-(2-azidoethyl)-4-bromoindole and facilitates the rapid construction of the lower aminal-containing tetracyclic core of the natural product.
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