Iridium-Catalyzed Enantioselective Polyene Cyclization
Journal of the American Chemical Society2012Vol. 134(50), pp. 20276–20278
Citations Over TimeTop 1% of 2012 papers
Abstract
A highly enantioselective polycyclization method has been developed using the combination of Lewis acid activation with iridium-catalyzed allylic substitution. This strategy relies on direct use of branched, racemic allylic alcohols and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields and ≥99% ee.
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