Isomerization of Terminal Epoxides by a [Pd–H] Catalyst: A Combined Experimental and Theoretical Mechanistic Study
Journal of the American Chemical Society2013Vol. 135(16), pp. 6177–6183
Citations Over TimeTop 10% of 2013 papers
Abstract
An unusual palladium hydride complex has been shown to be a competent catalyst in the isomerization of a variety of terminal and internal epoxides. The reaction displayed broad scope and synthetic utility. Experimental and theoretical evidence are provided for an unprecedented hydride mechanism characterized by two distinct enantio-determining steps. These results hold promise for the development of an enantioselective variant of the reaction.
Related Papers
- → Recent developments in enantioselective iron-catalyzed transformations(2019)58 cited
- → Methods of Asymmetric Synthesis—Enantioselective Catalytic Hydrogenation(1971)142 cited
- → Isomerization reactions of n-hexane on partially reduced MoO3/TiO2(2007)33 cited
- → Chiral B(III) Lewis Acids(2000)19 cited
- → Isomerization(2017)