Catalytic Enantioselective Epoxidation of Tertiary Allylic and Homoallylic Alcohols
Journal of the American Chemical Society2013Vol. 135(9), pp. 3411–3413
Citations Over TimeTop 10% of 2013 papers
Abstract
An efficient and versatile method for the enantioselective epoxidation of both tertiary allylic and homoallylic alcohols catalyzed by Hf(IV)-bishydroxamic acid (BHA) complexes is described. Asymmetric epoxidation, kinetic resolution, and desymmetrization have been developed, demonstrating the flexible nature of the Hf(IV)-BHA system. This is the first report in which these substrates were obtained with enantioselectivities of up to 99%.
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