Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells
Journal of the American Chemical Society2013Vol. 135(37), pp. 13632–13635
Citations Over TimeTop 10% of 2013 papers
Abstract
A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide-oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.
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