Bioconjugation by Native Chemical Tagging of C–H Bonds
Journal of the American Chemical Society2013Vol. 135(35), pp. 12994–12997
Citations Over TimeTop 10% of 2013 papers
Qianghui Zhou, Jinghan Gui, Chung‐Mao Pan, Earl F. Albone, Xin Cheng, Edward M. Suh, Luigi Grasso, Yoshihiro Ishihara, Phil S. Baran
Abstract
A general C–H functionalization method for the tagging of natural products and pharmaceuticals is described. An azide-containing sulfinate reagent allows the appendage of azidoalkyl chains onto heteroaromatics, the product of which can then be attached to a monoclonal antibody by a “click” reaction. This strategy expands the breadth of bioactive small molecules that can be linked to macromolecules in a manner that is beyond the scope of existing methods in bioconjugation to permit tagging of the “seemingly untaggable”.
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