Asymmetric Epoxidation with H₂O₂ by Manipulating the Electronic Properties of Non-heme Iron Catalysts

Citations Over TimeTop 10% of 2013 papers

Abstract

A non-heme iron complex that catalyzes highly enantioselective epoxidation of olefins with H2O2 is described. Improvement of enantiomeric excesses is attained by the use of catalytic amounts of carboxylic acid additives. Electronic effects imposed by the ligand on the iron center are shown to synergistically cooperate with catalytic amounts of carboxylic acids in promoting efficient O-O cleavage and creating highly chemo- and enantioselective epoxidizing species which provide a broad range of epoxides in synthetically valuable yields and short reaction times.

Related Papers

• → Enantiomeric enrichment of non-racemic mixtures of binaphthol with non-chiral packings(1996)47 cited
• → Enantiomeric enrichment by the use of density differences between racemic compounds and optically active enantiomers(1995)16 cited
• → Highly enantioselective asymmetric autocatalysis of 2‐alkenyl‐ and 2‐vinyl‐5‐pyrimidyl alkanols with significant amplification of enantiomeric excess(2002)31 cited
• → Colour indicator for enantiomeric excess and assignment of the configuration of the major enantiomer of an amino acid ester(2002)26 cited
• → A method for determining the enantiomeric purity of profens(2009)14 cited