Nitric Oxide Releasing Materials Triggered by Near-Infrared Excitation Through Tissue Filters

Citations Over TimeTop 10% of 2013 papers

Abstract

Novel materials for the phototherapeutic release of the bioregulator nitric oxide (nitrogen monoxide) are described. Also reported is a method for scanning these materials with a focused NIR beam to induce photouncaging while minimizing damage from local heating. The new materials consist of poly(dimethylsiloxane) composites with near-infrared-to-visible upconverting nanoparticles (UCNPs) that are cast into a biocompatible polymer disk (PD). These PDs are then impregnated with the photochemical nitric oxide precursor Roussin's black salt (RBS) to give UCNP_RBS_PD devices that generate NO when irradiated with 980 nm light. When the UCNP_RBS_PD composites were irradiated with NIR light through filters composed of porcine tissue, physiologically relevant NO concentrations were released, thus demonstrating the potential of such devices for minimally invasive phototherapeutic applications.

Related Papers

• Nitric oxide :principles and actions(1996)
• → Multifunctional role of nitric oxide in inflammation(1994)108 cited
• → Selective Fluorescent Activation for Bioimaging the Expression of Nitric Oxide in Cellular and In Vivo Systems(2010)1 cited
• → Methods for obtaining and processing biocompatible medical materials(2019)
• → [Research advances on the application of biocompatible materials in treating diabetic wounds].(2021)