Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels
Journal of the American Chemical Society2013Vol. 136(2), pp. 574–577
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Jing Liu, Yuanqiang Sun, Yingying Huo, Hong‐Xing Zhang, Linfang Wang, Pei Zhang, Dan Song, Yawei Shi, Wei Guo
Abstract
A chlorinated coumarin-hemicyanine dye with three potential reaction sites was exploited as fluorescent probe for biothiols. The Cys-induced substitution-rearrangement-cyclization, Hcy-induced substitution-rearrangement, and GSH-induced substitution-cyclizatioin cascades lead to the corresponding amino-coumarin, amino-coumarin-hemicyanine, thiol-coumarin with distinct photophysical properties, enabling Cys and GSH to be selectively detected from different emission channels at two different excitation wavelengths.
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