Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes
Journal of the American Chemical Society2013Vol. 136(3), pp. 894–897
Citations Over TimeTop 1% of 2013 papers
Gui‐Juan Cheng, Yun‐Fang Yang, Peng Liu, Ping Chen, Tian‐Yu Sun, Gang Li, Xinhao Zhang, K. N. Houk, Jin‐Quan Yu, Yun‐Dong Wu
Abstract
A combined experimental/computational study on the amino acid ligand-assisted Pd-catalyzed C-H bond activation reveals a mechanism in which the amino acid acts as both a dianionic bidentate ligand and a proton acceptor. This new model explains the effects of amino acids on reactivity and selectivity and unveils the dual roles of amino acids: stabilizing monomeric Pd complexes and serving as the internal base for proton abstraction.
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