Directing Neuronal Signaling through Cell-Surface Glycan Engineering
Journal of the American Chemical Society2014Vol. 136(19), pp. 6794–6797
Citations Over TimeTop 10% of 2014 papers
Abstract
The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced axonal growth. This approach provides a facile, general route to tailor cell membranes with biologically active glycans and demonstrates the potential to direct important cellular events through cell-surface glycan engineering.
Related Papers
- → Chondroitin Sulfate N -acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain(2021)16 cited
- → Preparing Size-Controlled Liposomes Modified with Polysaccharide Derivatives for pH-Responsive Drug Delivery Applications(2023)12 cited
- → Effect of liposome type and membrane fluidity on drug–membrane partitioning analyzed by immobilized liposome chromatography(2001)68 cited
- → Complement Dependent and Independent Liposome Uptake by Peritoneal Macrophages: Cholesterol Content Dependency.(1998)17 cited
- → Rates of Systemic Degradation and Reticuloendothelial System (RES) Uptake of Thermosensitive Liposome Encapsulating Cisplatin in Rats(1993)5 cited