Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
Journal of the American Chemical Society2014Vol. 136(10), pp. 3792–3795
Citations Over TimeTop 1% of 2014 papers
Abstract
On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
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