A Superfluorinated Molecular Probe for Highly Sensitive in Vivo19F-MRI
Journal of the American Chemical Society2014Vol. 136(24), pp. 8524–8527
Citations Over TimeTop 10% of 2014 papers
Ilaria Tirotta, Alfonso Mastropietro, Chiara Cordiglieri, Lara Gazzera, Fulvio Baggi, Giuseppe Baselli, Maria Grazia Bruzzone, Ileana Zucca, Gabriella Cavallo, Giancarlo Terraneo, Francesca Baldelli Bombelli, Pierangelo Metrangolo, Giuseppe Resnati
Abstract
(19)F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo (19)F-MRI applications. The molecule, which bears 36 equivalent (19)F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
Related Papers
- NMR spectroscopy of the non-metallic elements(1997)
- → Molecular probes for the in vivo imaging of cancer(2009)73 cited
- → Solvent Effects Used for Optimal Simultaneous Analysis of Amino Acids via 19F NMR Spectroscopy(2023)17 cited
- → In Vivo Molecular Imaging for Biomedical Analysis and Therapies(2018)16 cited
- → In Vivo NMR Spectroscopy – Static Aspects(2007)10 cited