Cell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins
Journal of the American Chemical Society2014Vol. 136(28), pp. 9830–9833
Citations Over TimeTop 10% of 2014 papers
Abstract
Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically stable, and biologically active inhibitors against the enzymes.
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