Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers
Journal of the American Chemical Society2014Vol. 136(39), pp. 13709–13714
Citations Over TimeTop 10% of 2014 papers
Andrew Warren, Shonda T. Gaylord, Kevin C. Ngan, Miléna Milutinovic, Gabriel A. Kwong, Sangeeta N. Bhatia, David R. Walt
Abstract
The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for "microdosing."
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