Palladium-Catalyzed Oxidative Ethoxycarbonylation of Aromatic C−H Bond with Diethyl Azodicarboxylate
Journal of the American Chemical Society2008Vol. 130(11), pp. 3304–3306
Citations Over TimeTop 1% of 2008 papers
Abstract
This communication describes the Pd(OAc)2-catalyzed ethoxycarbonylation reactions of aromatic C−H bonds using diethyl azodicarboxylate (DEAD) together with Oxone or K2S2O8. Substrates such as 2-arylpyridines, pyrrolidinone, acetylindoline, quinoline, and oximes were ethoxycarbonylated with excellent chemo- and regioselectivities. The catalytic reaction is probably initiated by chelation-assisted cyclopalladation of the ortho-C−H bond. Preliminary studies suggested that reactive ethoxyacyl radicals generated from thermal decomposition of DEAD were involved in the ester formation.
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