Tandem Michael Addition/Ylide Epoxidation for the Synthesis of Highly Functionalized Cyclohexadiene Epoxide Derivatives
Journal of the American Chemical Society2008Vol. 130(16), pp. 5408–5409
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Qinggang Wang, Xianming Deng, Ben‐Hu Zhu, Long‐Wu Ye, Xiu‐Li Sun, Chuan‐Ying Li, Chunyin Zhu, Qi Shen, Yong Tang
Abstract
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
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