A Chiral Rhodium Carboxamidate Catalyst for Enantioselective C−H Amination
Journal of the American Chemical Society2008Vol. 130(29), pp. 9220–9221
Citations Over TimeTop 1% of 2008 papers
Abstract
Rh2(S-nap)4, a chiral dirhodium tetracarboxamidate complex, has been developed and shown to be an effective catalyst for the asymmetric, intramolecular C-H amination of sulfamate esters. Enantiomeric excesses range from 60-99% for a collection of disparately substituted 3-arylpropylsulfamates. In addition, Rh2(S-nap)4 is found to promote chemoselective allylic C-H oxidation of unsaturated sulfamates, a property not observed with other dirhodium complexes tested to date.
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