PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs
Citations Over TimeTop 1% of 2008 papers
Abstract
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nanographene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analogue, SN38, noncovalently via pi-pi stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA-approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.
Related Papers
- → Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells(2016)66 cited
- → Irinotecan chemotherapy associated with transient dysarthria and aphasia(2004)21 cited
- → Separation and purification of papain from papaya latex using aqueous two-phase extraction.(1989)5 cited
- The Evolving Role of Irinotecan: A Broad-Spectrum Chemotherapeutic Agent(2000)
- → Comparative Dft Studies of Cytotoxicity of Camptothecin, Irinotecan and Sn-38(2022)