Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles
Journal of the American Chemical Society2008Vol. 131(1), pp. 66–68
Citations Over TimeTop 10% of 2008 papers
Jih Ru Hwu, Yu Sern Lin, T. Josephrajan, Ming‐Hua Hsu, Fong‐Yu Cheng, Chen‐Sheng Yeh, Wu‐Chou Su, Dar‐Bin Shieh
Abstract
The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
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