Decarboxylative Biaryl Synthesis from Aromatic Carboxylates and Aryl Triflates
Journal of the American Chemical Society2008Vol. 130(46), pp. 15248–15249
Citations Over TimeTop 1% of 2008 papers
Abstract
A new catalyst system, generated in situ from Cu2O, 1,10-phenanthroline, PdI2, and Tol-BINAP, for the first time allows the decarboxylative coupling of carboxylic acids with aryl triflates. In contrast to previous decarboxylative couplings that remained limited to certain activated carboxylates, e.g., ortho-substituted benzoates, this halide-free protocol is generally applicable to aromatic carboxylic acid salts regardless of their substitution pattern.
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