Asymmetric Intramolecular Arylcyanation of Unactivated Olefins via C−CN Bond Activation
Journal of the American Chemical Society2008Vol. 130(38), pp. 12594–12595
Citations Over TimeTop 10% of 2008 papers
Abstract
The enantioselective, intramolecular arylcyanation of unactivated olefins via C-CN bond activation has been accomplished using a Ni(0) catalyst and BPh3 co-catalyst. High enantioselectivities are achieved using TangPHOS as a chiral ligand. This method allows the generation of two new C-C bonds and one new quaternary carbon stereogenic center in a single synthetic step, converting readily available benzonitrile substrates into 1,1-disubstituted indanes in 49-85% yield and 92-97% ee.
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