Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II
Journal of the American Chemical Society2008Vol. 130(48), pp. 16130–16131
Citations Over TimeTop 10% of 2008 papers
Maamar Stiti, Alessandro Cecchi, Marouan Rami, Mohamed Abdaoui, Véronique Barragan-Montero, Andrea Scozzafava, Yannick Guari≠, Jean‐Yves Winum, Claudiu T. Supuran
Abstract
An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.
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