Synthesis of Condensed Pyrroloindoles via Pd-Catalyzed Intramolecular C−H Bond Functionalization of Pyrroles
Journal of the American Chemical Society2008Vol. 130(48), pp. 16158–16159
Citations Over TimeTop 1% of 2008 papers
Abstract
A new strategy for the synthesis of condensed hetero- or carbocycles such as pyrroloindoles or fluorenes has been developed that involves the Pd-catalyzed cyclization of readily available N-(2-halobenzyl)pyrroles or their phenyl derivatives. The reaction is proposed to proceed via oxidative addition of benzylic halides to Pd(0) followed by base-assisted C-H bond activation. A broad range of condensed cyclic products could be obtained in good to excellent yields under mild conditions.
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