Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes
Journal of the American Chemical Society2008Vol. 130(47), pp. 15786–15787
Citations Over TimeTop 10% of 2008 papers
Abstract
A highly enantioselective Brønsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several antihypertensive aminal drugs including (R)-Thiabutazide.
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