Light-Regulated Activation of Cellular Signaling by Gold Nanoparticles That Capture and Release Amines
Journal of the American Chemical Society2009Vol. 131(11), pp. 3822–3823
Citations Over TimeTop 10% of 2009 papers
Jun Nakanishi, Hidekazu Nakayama, Takahiro Shimizu, Haruhisa Ishida, Yukiko Kikuchi, Kazuo Yamaguchi, Yasuhiro Horiike
Abstract
A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.
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