Catalytic Transamidation Reactions Compatible with Tertiary Amide Metathesis under Ambient Conditions
Journal of the American Chemical Society2009Vol. 131(29), pp. 10003–10008
Citations Over TimeTop 10% of 2009 papers
Abstract
The carbon-nitrogen bond of carboxamides is extremely stable under most conditions. The present study reveals that simple zirconium- and hafnium-amido complexes are highly efficient catalysts for equilibrium-controlled transamidation reactions between secondary amines and tertiary amides. In a number of cases, transamidation proceeds rapidly at room temperature. We find that these new catalysts are sufficiently active to promote the metathesis of tertiary amides, which arises from successive transamidation cycles. The catalytic activities we observe are unprecedented and represent a substantial step toward a long-range goal of conducting equilibrium-controlled reactions with carboxamides.
Related Papers
- → Organometallic Chemistry of Transition Metal Alkylidyne Complexes Centered at Metathesis Reactions(2022)44 cited
- → Metathesis of C4 olefin over Mo-based heterogeneous catalysts: A novel route to propene and isopentene(2012)19 cited
- → 4902764 Polymeric sulfide mineral depressants(1990)2 cited
- → Metathesis Reactions in Solid‐Phase Organic Synthesis(2010)2 cited
- → Nanoparticulate gold oxidation catalyst(2003)